The Department of Pediatrics’ divisions and programs work individually and collaboratively to improve the health and well-being of children and their families through research.
We work to provide interventions before serious illnesses or injuries happen. We investigate the best ways to treat and provide follow up care for medical conditions.
We accomplish our goals through a combination of laboratory research and clinical trials. In many of our preliminary studies, we look for clues to determine the best course forward. The programs of Children’s Memorial Research Center are committed to making discoveries that will improve the lives of children and their families. Clinical trials conducted by our divisions provide opportunities for, and the responsibility of dramatically improving therapeutics and finding cures for illnesses and diseases.
Food allergies in children are more common than previously believed. Ruchi Gupta and colleagues published data suggesting that one in 13 U.S. children suffers from food allergies, a figure that is double the latest government estimate.
Wound healing dramatically improved. Amy Paller’s laboratory found that depletion of membrane gangliosides dramatically increases the proliferation and migration of keratinocytes and the healing of wounds in animal models.
Children with epilepsy have a higher prevalence of autism spectrum disorder. Anne Berg and colleagues conducted a community-based study and found the percentage of these children with autism spectrum disorder to be significantly higher than in the general population.
VEGF contributes to early lung disease. Susanna McColley and Kimberly Watts believe that elevated levels of serum vascular endothelial factor (VEGF) in children with cystic fibrosis (CF) are contributing to early lung disease.
Biomarkers may help to assess inflammation. Marisa Klein-Gitelman is working with a research network to define biomarkers of lupus brain and kidney inflammation as well as better measures of disease flare and remission.